@article{pittir20493, volume = {66}, number = {9}, month = {May}, author = {P Wipf and CR Hopkins}, title = {Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine}, journal = {Journal of Organic Chemistry}, pages = {3133 -- 3139}, year = {2001}, url = {http://d-scholarship-dev.library.pitt.edu/20493/}, abstract = {The synthesis of the 1,2,3,4-tetrahydroisoquinoline moiety of tetrazomine was accomplished in 18 steps and in 3\% overall yield from commercially available o-anisaldehyde. The reaction sequence utilizes a Sharpless asymmetric dihydroxylation to install the stereocenter and an intramolecular Friedel-Crafts hydroxyalkylation with an N-protected 2-oxo-acetamide to close the heterocyclic ring.} }