%A AE Gabarda
%A W Du
%A T Isarno
%A RS Tangirala
%A DP Curran
%J Tetrahedron
%T Asymmetric total synthesis of (20R)-homocamptothecin, substituted homocamptothecins and homosilatecans
%X An efficient asymmetric synthesis of a key DE lactone pyridone intermediate in the synthesis of homocamptothecin is reported. The synthesis is scalable and features a Stille coupling and a Sharpless asymmetric epoxidation as the key steps. The key intermediate has been parleyed into homocamptothecin and an assortment of fluorinated homocamptothecins and homosilatecans (7-silylhomocamptothecins), thereby providing the first asymmetric entry to this important new class of antitumor agents. ? 2002 Published by Elsevier Science Ltd.
%N 32
%P 6329 - 6341
%V 58
%D 2002
%R 10.1016/S0040-4020(02)00632-4
%L pittir20486