TY  - JOUR
ID  - pittir20486
UR  - http://d-scholarship-dev.library.pitt.edu/20486/
IS  - 32
A1  - Gabarda, AE
A1  - Du, W
A1  - Isarno, T
A1  - Tangirala, RS
A1  - Curran, DP
Y1  - 2002/08/05/
N2  - An efficient asymmetric synthesis of a key DE lactone pyridone intermediate in the synthesis of homocamptothecin is reported. The synthesis is scalable and features a Stille coupling and a Sharpless asymmetric epoxidation as the key steps. The key intermediate has been parleyed into homocamptothecin and an assortment of fluorinated homocamptothecins and homosilatecans (7-silylhomocamptothecins), thereby providing the first asymmetric entry to this important new class of antitumor agents. © 2002 Published by Elsevier Science Ltd.
JF  - Tetrahedron
VL  - 58
SN  - 0040-4020
TI  - Asymmetric total synthesis of (20R)-homocamptothecin, substituted homocamptothecins and homosilatecans
SP  - 6329 
AV  - public
EP  -  6341
ER  -