%0 Journal Article
%@ 0040-4020
%A Gabarda, AE
%A Du, W
%A Isarno, T
%A Tangirala, RS
%A Curran, DP
%D 2002
%F pittir:20486
%J Tetrahedron
%N 32
%P 6329 - 6341
%T Asymmetric total synthesis of (20R)-homocamptothecin, substituted homocamptothecins and homosilatecans
%U http://d-scholarship-dev.library.pitt.edu/20486/
%V 58
%X An efficient asymmetric synthesis of a key DE lactone pyridone intermediate in the synthesis of homocamptothecin is reported. The synthesis is scalable and features a Stille coupling and a Sharpless asymmetric epoxidation as the key steps. The key intermediate has been parleyed into homocamptothecin and an assortment of fluorinated homocamptothecins and homosilatecans (7-silylhomocamptothecins), thereby providing the first asymmetric entry to this important new class of antitumor agents. © 2002 Published by Elsevier Science Ltd.