%A P Wipf
%A C Kendall
%J Organic Letters
%T Tandem zirconocene homologation-aldimine allylation
%X (Equation presented) Hydrozirconation of internal and terminal alkynes followed by in situ transmetalation to dimethylzinc and treatment with diiodomethane leads to chain extended allylic organometallics. Addition to N-phosphinoyl or N-sulfonyl aldimines provides homoallylic amines in 48-87% yield and 3:2 to >20:1 diastereomeric ratios favoring anti-products.
%N 17
%P 2773 - 2776
%V 3
%D 2001
%R 10.1021/ol0163880
%L pittir20481