eprintid: 20480
rev_number: 21
userid: 1418
dir: disk0/00/02/04/80
datestamp: 2014-02-07 00:02:56
lastmod: 2019-03-30 14:55:23
status_changed: 2014-02-07 00:02:56
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Shin, Y
creators_name: Choy, N
creators_name: Balachandran, R
creators_name: Madiraju, C
creators_name: Day, BW
creators_name: Curran, DP
creators_email: 
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creators_email: 
creators_email: 
creators_email: 
creators_email: curran@pitt.edu
creators_id: 
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creators_id: 
creators_id: 
creators_id: CURRAN
title: Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: (Matrix Presented) Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.
date: 2002-12-12
date_type: published
publication: Organic Letters
volume: 4
number: 25
pagerange: 4443 - 4446
refereed: TRUE
issn: 1523-7060
id_number: 10.1021/ol026942l
pmid: 12465908
mesh_headings: Alkanes
mesh_headings: Antineoplastic Agents--chemical synthesis
mesh_headings: Antineoplastic Agents--chemistry
mesh_headings: Antineoplastic Agents--pharmacology
mesh_headings: Breast Neoplasms--drug therapy
mesh_headings: Breast Neoplasms--pathology
mesh_headings: Carbamates
mesh_headings: Female
mesh_headings: Humans
mesh_headings: Lactones--chemical synthesis
mesh_headings: Lactones--chemistry
mesh_headings: Lactones--pharmacology
mesh_headings: Macrolides
mesh_headings: Ovarian Neoplasms--drug therapy
mesh_headings: Ovarian Neoplasms--pathology
mesh_headings: Pyrones
mesh_headings: Tumor Cells, Cultured
chemical_names: Alkanes
chemical_names: Antineoplastic Agents
chemical_names: Carbamates
chemical_names: Lactones
chemical_names: Macrolides
chemical_names: Pyrones
chemical_names: dictyostatin
chemical_names: discodermolide
citation:   Shin, Y and Choy, N and Balachandran, R and Madiraju, C and Day, BW and Curran, DP  (2002) Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation.  Organic Letters, 4 (25).  4443 - 4446.  ISSN 1523-7060     
document_url: http://d-scholarship-dev.library.pitt.edu/20480/1/licence.txt