%0 Journal Article
%@ 0968-0896
%A Du, W
%A Kaskar, B
%A Blumbergs, P
%A Subramanian, PK
%A Curran, DP
%D 2003
%F pittir:20479
%J Bioorganic and Medicinal Chemistry
%N 3
%P 451 - 458
%T Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals
%U http://d-scholarship-dev.library.pitt.edu/20479/
%V 11
%X Thiol- or acid-promoted additions of silyl radicals to camptothecin are reported. At 105°C, mixtures of 7-silyl (favored) and 12-silyl camptothecins are formed alongside substantial amounts of recovered camptothecin. At 160°C, 12-silyl isomers are formed preferentially, but the total mass balance is substantially reduced. The silyl radical addition is featured in short semi-syntheses of DB-67 (7-tert-butyldimethylsilyl-10-hydroxy camptothecin) from both camptothecin and 10-hydroxycamptothecin. © 2002 Elsevier Science Ltd. All rights reserved.