@article{pittir20443, number = {9 SPEC}, month = {January}, title = {Cascade 4+1 radical annulations of 2,6-disubstituted phenyl isonitriles with N-propargyl-6-iodopyridones: Scope, mechanism and regioselective synthesis of 7,9-disubstituted camptothecin analogs}, author = {W Du and DP Curran}, year = {2003}, pages = {1299 -- 1302}, journal = {Synlett}, url = {http://d-scholarship-dev.library.pitt.edu/20443/}, abstract = {The reaction of o,o?-dialkyl-substituted aryl isonitriles with N-propargyl-6-iodopyridones provides 11H-indolizino[1,2-b]quinolin-9-ones with significant regioselectivity in favor of the more crowded product. The usefulness of the method is illustrated with a regioselective synthesis of (20S)-7-trimethylsilyl-9-isopropyl camptothecin.} }