eprintid: 20433
rev_number: 18
userid: 1419
dir: disk0/00/02/04/33
datestamp: 2014-01-30 18:25:47
lastmod: 2020-07-04 14:55:10
status_changed: 2014-01-30 18:25:47
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Lazo, JS
creators_name: Wipf, P
creators_email: 
creators_email: pwipf@pitt.edu
creators_id: 
creators_id: PWIPF
title: Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: Small molecules provide exceptionally useful tools for probing signaling targets relevant for cancer and stem cell differentiation. In contrast to genetic approaches, the application of small molecules generally offers a graded and reversible disruption of a particular pathway. The vast array of theoretical chemical entities that exist in the chemical universe are now becoming available through the production and distribution of chemical libraries generated by both traditional and combinatorial methods, which are suitable for pharmacological use. Convenient and inexpensive cell-free and cell-based assays can be used to identify chemicals that exhibit desirable antisignaling properties. We illustrate a model of how agents targeted against signaling macromolecules involved in cancer, namely dual specificity protein phosphatases, can be identified.
date: 2002-01-01
date_type: published
publication: Oncology Research
volume: 13
number: 6-10
pagerange: 347 - 352
refereed: TRUE
issn: 0965-0407
id_number: 10.3727/096504003108748555
pmid: 12725524
mesh_headings: Antineoplastic Agents--pharmacology
mesh_headings: Cell Cycle--drug effects
mesh_headings: Cell Transformation, Neoplastic--metabolism
mesh_headings: Enzyme Inhibitors--pharmacology
mesh_headings: Humans
mesh_headings: Models, Biological
mesh_headings: Models, Molecular
mesh_headings: Signal Transduction--physiology
mesh_headings: cdc25 Phosphatases--classification
mesh_headings: cdc25 Phosphatases--drug effects
chemical_names: Antineoplastic Agents
chemical_names: Enzyme Inhibitors
chemical_names: cdc25 Phosphatases
citation:   Lazo, JS and Wipf, P  (2002) Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways.  Oncology Research, 13 (6-10).  347 - 352.  ISSN 0965-0407     
document_url: http://d-scholarship-dev.library.pitt.edu/20433/1/licence.txt