eprintid: 20429
rev_number: 16
userid: 1418
dir: disk0/00/02/04/29
datestamp: 2014-01-30 18:11:19
lastmod: 2019-02-02 15:58:39
status_changed: 2014-01-30 18:11:19
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Gabarda, AE
creators_name: Curran, DP
creators_email: 
creators_email: curran@pitt.edu
creators_id: 
creators_id: CURRAN
title: Solution-phase parallel synthesis of 115 homosilatecan analogues
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: The parallel synthesis of 115 homosilatecans on 1-5 mg scale has been accomplished. Key reactions include N-propargylation of a common iodopyridone lactone with a silyl-substituted propargyl bromide, followed by cascade radical annulation with a substituted isonitrile. Simple manual techniques for parallel reactions were coupled with automated purifications (SPE, HPLC) to give high-purity final products. The speed and simplicity of the automated purification protocol more than compensated for yield losses in the synthesis of some analogues relative to traditional flash chromatographic purifications.
date: 2003-09-01
date_type: published
publication: Journal of Combinatorial Chemistry
volume: 5
number: 5
pagerange: 617 - 624
refereed: TRUE
issn: 1520-4766
id_number: 10.1021/cc030018g
citation:   Gabarda, AE and Curran, DP  (2003) Solution-phase parallel synthesis of 115 homosilatecan analogues.  Journal of Combinatorial Chemistry, 5 (5).  617 - 624.  ISSN 1520-4766     
document_url: http://d-scholarship-dev.library.pitt.edu/20429/1/licence.txt