TY  - JOUR
ID  - pittir20425
UR  - http://d-scholarship-dev.library.pitt.edu/20425/
IS  - 11
A1  - Wipf, P
A1  - Lynch, SM
A1  - Birmingham, A
A1  - Tamayo, G
A1  - Jiménez, A
A1  - Campos, N
A1  - Powis, G
Y1  - 2004/06/07/
N2  - Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to > 100 ?M.
JF  - Organic and Biomolecular Chemistry
VL  - 2
SN  - 1477-0520
TI  - Natural product based inhibitors of the thioredoxin-thioredoxin reductase system
SP  - 1651 
AV  - public
EP  -  1658
ER  -