<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Natural product based inhibitors of the thioredoxin-thioredoxin reductase system"^^ . "Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to > 100 μM."^^ . "2004-06-07" . . "2" . "11" . . "Organic and Biomolecular Chemistry"^^ . . . "14770520" . . . . . . . . . . . . . . . . . . . . . . . . . "G"^^ . "Tamayo"^^ . "G Tamayo"^^ . . "SM"^^ . "Lynch"^^ . "SM Lynch"^^ . . "G"^^ . "Powis"^^ . "G Powis"^^ . . "N"^^ . "Campos"^^ . "N Campos"^^ . . "A"^^ . "Birmingham"^^ . "A Birmingham"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "A"^^ . "Jiménez"^^ . "A Jiménez"^^ . . . . . . "Natural product based inhibitors of the thioredoxin-thioredoxin reductase system (Plain Text)"^^ . . . "licence.txt"^^ . . . "Natural product based inhibitors of the thioredoxin-thioredoxin reductase system (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20425 \n\nNatural product based inhibitors of the thioredoxin-thioredoxin reductase system\n\n" . "text/html" . .