@article{pittir20425,
          volume = {2},
          number = {11},
           month = {June},
          author = {P Wipf and SM Lynch and A Birmingham and G Tamayo and A Jim{\'e}nez and N Campos and G Powis},
           title = {Natural product based inhibitors of the thioredoxin-thioredoxin reductase system},
         journal = {Organic and Biomolecular Chemistry},
           pages = {1651 -- 1658},
            year = {2004},
             url = {http://d-scholarship-dev.library.pitt.edu/20425/},
        abstract = {Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to {\ensuremath{>}} 100 {\ensuremath{\mu}}M.}
}