<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity"^^ . "The molecular chaperone and cytoprotective activities of the Hsp70 and Hsp40 chaperones represent therapeutic targets for human diseases such as cancer and those that arise from defects in protein folding; however, very few Hsp70 and no Hsp40 modulators have been described. Using an assay for ATP hydrolysis, we identified and screened small molecules with structural similarity to 15-deoxyspergualin and NSC 630668-R/1 for their effects on endogenous and Hsp40-stimulated Hsp70 ATPase activity. Several of these compounds modulated Hsp70 ATPase activity, consistent with the action of NSC 630668-R/1 observed previously (Fewell, S. W., Day, B. W., and Brodsky, J. L. (2001) J. Biol. Chem. 276, 910-914). In contrast, three compounds inhibited the ability of Hsp40 to stimulate Hsp70 ATPase activity but did not affect the endogenous activity of Hsp70. Two of these agents also compromised the Hsp70/Hsp40-mediated post-translational translocation of a secreted pre-protein in vitro. Together, these data indicate the potential for continued screening of small molecule Hsp70 effectors and that specific modulators of Hsp70-Hsp40 interaction can be obtained, potentially for future therapeutic use."^^ . "2004-12-03" . . "279" . "49" . . "Journal of Biological Chemistry"^^ . . . "00219258" . . . . . . . . . . . . . . . . . . . . . . . . . "MA"^^ . "Lyon"^^ . "MA Lyon"^^ . . "SW"^^ . "Fewell"^^ . "SW Fewell"^^ . . "BW"^^ . "Day"^^ . "BW Day"^^ . . "CM"^^ . "Smith"^^ . "CM Smith"^^ . . "JL"^^ . "Brodsky"^^ . "JL Brodsky"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "TP"^^ . "Dumitrescu"^^ . "TP Dumitrescu"^^ . . . . . . "Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity (Plain Text)"^^ . . . "licence.txt"^^ . . . "Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20393 \n\nSmall molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity\n\n" . "text/html" . .