<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides"^^ . "A new structural scaffold for antiestrogens was identified from the cell-based screening of a 67-member library of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. Several derivatives had activity comparable to that of tamoxifen. A new structural scaffold for antiestrogens was identified from the cell-based screening of transcriptional regulation properties of a 67-member library of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. C-Cyclopropylalkylamide 3a (O-ethyl-N-{2-[(1S*, 2R*)-2-{(R*)-[(diphenylphosphinoyl)amino](phenyl)methyl}cyclopropyl] ethyl}-N-[(4-methylphenyl)sulfonyl]carbamate) had antagonistic activity similar to that of tamoxifen and was further evaluated. Compound 3a inhibited estradiol-induced proliferation of the ER-positive MCF-7 cells but had no effect on ER-negative MDA-MB231 human breast cancer cells. Furthermore, high micromolar concentrations of 3a exhibited minimal cytotoxicity to the ER-negative line. The biological activities of the enantiomers of 3a did not differ from one another nor from that of racemic 3a. © 2004 Elsevier Ltd. All rights reserved."^^ . "2005-01-03" . . "13" . "1" . . "Bioorganic and Medicinal Chemistry"^^ . . . "09680896" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "BW"^^ . "Day"^^ . "BW Day"^^ . . "JM"^^ . "Janjic"^^ . "JM Janjic"^^ . . "W"^^ . "Xie"^^ . "W Xie"^^ . . "R"^^ . "Balachandran"^^ . "R Balachandran"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "Y"^^ . "Lu"^^ . "Y Lu"^^ . . "C"^^ . "Kendall"^^ . "C Kendall"^^ . . "CRJ"^^ . "Stephenson"^^ . "CRJ Stephenson"^^ . . "BS"^^ . "Raccor"^^ . "BS Raccor"^^ . . "Y"^^ . "Mu"^^ . "Y Mu"^^ . . "G"^^ . "Zhu"^^ . "G Zhu"^^ . . . . . . "New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides (Plain Text)"^^ . . . "licence.txt"^^ . . . "New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20392 \n\nNew antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides\n\n" . "text/html" . .