%A Daniel M.  Brody
%T Synthesis of Simplified Discodermolide Analogs
%X Discodermolide was discovered in 1990 and with its discovery set off an expansive
medicinal chemistry program fueled by many groups? research. It acts as a microtubule
stabilizer, which makes it a potential anti-cancer agent. The synthesis of simplified
discodermolide analogs is reported here. These analogs use simplified versions of the lactone
and carbamate fragments, which are then coupled via olefin metathesis. Hologram quantitative
structure-activity relationship (HQSAR) is also used to show that an olefin linker inserted by
olefin metathesis as viable simple alternatives to the complex middle portion usually found in the
parent molecule.
%D 2014
%K Discodermolide, Microtubules, Microtubule stabilizers
%I University of Pittsburgh
%L pittir20243