<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Synthesis of Simplified Discodermolide Analogs"^^ . "Discodermolide was discovered in 1990 and with its discovery set off an expansive\r\nmedicinal chemistry program fueled by many groups’ research. It acts as a microtubule\r\nstabilizer, which makes it a potential anti-cancer agent. The synthesis of simplified\r\ndiscodermolide analogs is reported here. These analogs use simplified versions of the lactone\r\nand carbamate fragments, which are then coupled via olefin metathesis. Hologram quantitative\r\nstructure-activity relationship (HQSAR) is also used to show that an olefin linker inserted by\r\nolefin metathesis as viable simple alternatives to the complex middle portion usually found in the\r\nparent molecule."^^ . "2014-01-27" . . . . . . . . "Daniel M. "^^ . "Brody"^^ . "Daniel M. Brody"^^ . . . . . . "Synthesis of Simplified Discodermolide Analogs (PDF)"^^ . . . . . . "DBrody_Thesis_1.pdf"^^ . . . "Synthesis of Simplified Discodermolide Analogs (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "Synthesis of Simplified Discodermolide Analogs (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Synthesis of Simplified Discodermolide Analogs (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Synthesis of Simplified Discodermolide Analogs (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Synthesis of Simplified Discodermolide Analogs (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #20243 \n\nSynthesis of Simplified Discodermolide Analogs\n\n" . "text/html" . .