?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F20243%2F&rft.title=Synthesis+of+Simplified+Discodermolide+Analogs&rft.creator=Brody%2C+Daniel+M.+&rft.description=Discodermolide+was+discovered+in+1990+and+with+its+discovery+set+off+an+expansive%0D%0Amedicinal+chemistry+program+fueled+by+many+groups%E2%80%99+research.+It+acts+as+a+microtubule%0D%0Astabilizer%2C+which+makes+it+a+potential+anti-cancer+agent.+The+synthesis+of+simplified%0D%0Adiscodermolide+analogs+is+reported+here.+These+analogs+use+simplified+versions+of+the+lactone%0D%0Aand+carbamate+fragments%2C+which+are+then+coupled+via+olefin+metathesis.+Hologram+quantitative%0D%0Astructure-activity+relationship+(HQSAR)+is+also+used+to+show+that+an+olefin+linker+inserted+by%0D%0Aolefin+metathesis+as+viable+simple+alternatives+to+the+complex+middle+portion+usually+found+in+the%0D%0Aparent+molecule.&rft.date=2014-01-27&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F20243%2F1%2FDBrody_Thesis_1.pdf&rft.identifier=++Brody%2C+Daniel+M.+++(2014)+Synthesis+of+Simplified+Discodermolide+Analogs.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++