relation: http://d-scholarship-dev.library.pitt.edu/19936/ title: Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system creator: Wipf, P creator: Lynch, SM creator: Powis, G creator: Birmingham, A creator: Englund, EE description: A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile. © The Royal Society of Chemistry 2005. date: 2005-11-07 type: Article type: PeerReviewed format: text/plain language: en rights: attached identifier: http://d-scholarship-dev.library.pitt.edu/19936/1/licence.txt identifier: Wipf, P and Lynch, SM and Powis, G and Birmingham, A and Englund, EE (2005) Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system. Organic and Biomolecular Chemistry, 3 (21). 3880 - 3882. ISSN 1477-0520 relation: 10.1039/b510718k