@article{pittir19936, volume = {3}, number = {21}, month = {November}, author = {P Wipf and SM Lynch and G Powis and A Birmingham and EE Englund}, title = {Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system}, journal = {Organic and Biomolecular Chemistry}, pages = {3880 -- 3882}, year = {2005}, url = {http://d-scholarship-dev.library.pitt.edu/19936/}, abstract = {A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile. {\copyright} The Royal Society of Chemistry 2005.} }