TY  - JOUR
ID  - pittir19907
UR  - http://d-scholarship-dev.library.pitt.edu/19907/
IS  - 45
A1  - Woo, GHC
A1  - Kim, SH
A1  - Wipf, P
Y1  - 2006/11/06/
N2  - A novel and efficient protocol for the synthesis of the 3,8-diazabicyclo[3.2.1]octane system found in the naphthyridinomycin, dnacin, and tetrazomine families of alkaloids is described. The key transformation involves an intramolecular palladium-catalyzed allylic alkylation. The cyclization proceeds smoothly under mild conditions (20 mol % Pd2dba3, 1.5 equiv DBU, 65 °C, THF, 20 min) to afford 3,8-diazabicyclo[3.2.1]octanes in excellent yields (94-98%). © 2006 Elsevier Ltd. All rights reserved.
JF  - Tetrahedron
VL  - 62
SN  - 0040-4020
TI  - ?-Allyl palladium approach toward the diazabicyclo[3.2.1]octane core of the naphthyridinomycin alkaloids
SP  - 10507 
AV  - public
EP  -  10517
ER  -