relation: http://d-scholarship-dev.library.pitt.edu/19907/
title: π-Allyl palladium approach toward the diazabicyclo[3.2.1]octane core of the naphthyridinomycin alkaloids
creator: Woo, GHC
creator: Kim, SH
creator: Wipf, P
description: A novel and efficient protocol for the synthesis of the 3,8-diazabicyclo[3.2.1]octane system found in the naphthyridinomycin, dnacin, and tetrazomine families of alkaloids is described. The key transformation involves an intramolecular palladium-catalyzed allylic alkylation. The cyclization proceeds smoothly under mild conditions (20 mol % Pd2dba3, 1.5 equiv DBU, 65 °C, THF, 20 min) to afford 3,8-diazabicyclo[3.2.1]octanes in excellent yields (94-98%). © 2006 Elsevier Ltd. All rights reserved.
date: 2006-11-06
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/19907/1/licence.txt
identifier:   Woo, GHC and Kim, SH and Wipf, P  (2006) π-Allyl palladium approach toward the diazabicyclo[3.2.1]octane core of the naphthyridinomycin alkaloids.  Tetrahedron, 62 (45).  10507 - 10517.  ISSN 0040-4020     
relation: 10.1016/j.tet.2006.06.114