eprintid: 19888
rev_number: 12
userid: 1418
dir: disk0/00/01/98/88
datestamp: 2013-10-18 17:38:28
lastmod: 2017-10-15 06:55:28
status_changed: 2013-10-18 17:38:28
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Dandapani, S
creators_name: Curran, DP
creators_email: 
creators_email: curran@pitt.edu
creators_id: 
creators_id: CURRAN
title: Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: The Mitsunobu reaction is famous for its scope and power, but infamous for its separation headaches. Typically, the target product is enticed away from the reagent-derived byproducts by careful chromatography. The use of polymer-bound Mitsunobu reagents solves only half of the problem, because polymer-bound diethyl azodicarboxylate (DEAD) and phosphine reagents cannot be employed simultaneously. This article classifies, compares, and contrasts various emerging strategies for product isolation in Mitsunobu reactions. Because so many different strategies have been used, the Mitsunobu reaction is a microcosm for the new field of strategy level separations.
date: 2004-07-05
date_type: published
publication: Chemistry - A European Journal
volume: 10
number: 13
pagerange: 3130 - 3138
refereed: TRUE
issn: 0947-6539
id_number: 10.1002/chem.200400363
article_type: review
pmid: 15224321
mesh_headings: Alcohols--chemistry
mesh_headings: Alcohols--isolation & purification
mesh_headings: Azo Compounds--chemistry
mesh_headings: Azo Compounds--isolation & purification
mesh_headings: Chlorophenols--chemistry
mesh_headings: Chlorophenols--isolation & purification
mesh_headings: Combinatorial Chemistry Techniques--methods
mesh_headings: Dicarboxylic Acids--chemistry
mesh_headings: Dicarboxylic Acids--isolation & purification
mesh_headings: Hydrazines--chemistry
mesh_headings: Hydrazines--isolation & purification
mesh_headings: Organophosphorus Compounds--chemistry
mesh_headings: Organophosphorus Compounds--isolation & purification
chemical_names: Alcohols
chemical_names: Azo Compounds
chemical_names: Chlorophenols
chemical_names: Dicarboxylic Acids
chemical_names: Hydrazines
chemical_names: Organophosphorus Compounds
chemical_names: triphenylphosphine
chemical_names: 4-chlorophenol
chemical_names: triphenylphosphine oxide
citation:   Dandapani, S and Curran, DP  (2004) Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies.  Chemistry - A European Journal, 10 (13).  3130 - 3138.  ISSN 0947-6539     
document_url: http://d-scholarship-dev.library.pitt.edu/19888/1/licence.txt