relation: http://d-scholarship-dev.library.pitt.edu/19840/
title: Total synthesis of N<sup>14</sup>-desacetoxytubulysin H
creator: Wipf, P
creator: Wang, Z
description: Equation presented The N14-desacetoxy analogue of tubulysin H was prepared in 20 steps and 2.1% overall yield. Our strategy features a thiazole anion addition to assemble the tubuvaline residue at the C(10)-C(11) bond, as well as acylations at N5, N14, and N 17. This iterative coupling approach, as well as the removal of the labile N,O-acetal at N14, enables the synthesis of analogues for detailed studies of structure-activity relationships in this family of potent tubulin disrupters. © 2007 American Chemical Society.
date: 2007-04-12
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/19840/1/licence.txt
identifier:   Wipf, P and Wang, Z  (2007) Total synthesis of N<sup>14</sup>-desacetoxytubulysin H.  Organic Letters, 9 (8).  1605 - 1607.  ISSN 1523-7060     
relation: 10.1021/ol070415q