%A MR Lee
%A TL Raguse
%A M Schinnerl
%A WC Pomerantz
%A X Wang
%A P Wipf
%A SH Gellman
%J Organic Letters
%T Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in ?-peptides
%X ?-Peptides containing residues derived from trans-2- aminocyclohexanecarboxylic acid (ACHC) display high population of 14-helical secondary structure in aqueous solution. We show that hydrophobic interactions between cyclohexyl rings are not responsible for this conformationpromoting effect, and that polar groups may be attached to the cyclohexyl ring without diminishing the effect. ? 2007 American Chemical Society.
%N 9
%P 1801 - 1804
%V 9
%D 2007
%R 10.1021/ol070511r
%L pittir19809