relation: http://d-scholarship-dev.library.pitt.edu/19517/
title: Synthesis and biological evaluation of (-)-16-normethyldictyostatin: A potent analogue of (-)-dictyostatin
creator: Shin, Y
creator: Fournier, JH
creator: Balachandran, R
creator: Madiraju, C
creator: Raccor, BS
creator: Zhu, G
creator: Edler, MC
creator: Hamel, E
creator: Day, BW
creator: Curran, DP
description: (Chemical Equation Presented) (-)-16-Normethyldictyostatin has been made by total synthesis and is a potent antitumor agent in cells expressing wild-type tubulin and in one mutant cell line that is resistant to paclitaxel, but it is much less active than dictyostatin in another paclitaxel-resistant cell line where Val is substituted for Phe270. This provides strong evidence that the C16 methyl group of the dictyostatins is oriented toward Phe270 in the paclitaxel-binding site on β-tubulin. © 2005 American Chemical Society.
date: 2005-07-07
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/19517/1/licence.txt
identifier:   Shin, Y and Fournier, JH and Balachandran, R and Madiraju, C and Raccor, BS and Zhu, G and Edler, MC and Hamel, E and Day, BW and Curran, DP  (2005) Synthesis and biological evaluation of (-)-16-normethyldictyostatin: A potent analogue of (-)-dictyostatin.  Organic Letters, 7 (14).  2873 - 2876.  ISSN 1523-7060     
relation: 10.1021/ol050808u