<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin"^^ . "Both enantiomers of 20-fluorocamptothecin and the racemate have been prepared by total synthesis. The (R)-enantiomer is essentially inactive in a topoisomerase-I/DNA assay, while the (S)-enantiomer is much less active than (20S)-camptothecin. The lactone ring of 20-fluorocamptothecin hydrolyzes more rapidly than that of camptothecin in PBS. The results provide insight into the role of the 20-hydroxy group in the binding of camptothecin to topoisomerase-I and DNA. © 2005 Elsevier Ltd. All rights reserved."^^ . "2005-11-01" . . "15" . "21" . . "Bioorganic and Medicinal Chemistry Letters"^^ . . . "0960894X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . "A"^^ . "Ambrus"^^ . "A Ambrus"^^ . . "R"^^ . "Dixon"^^ . "R Dixon"^^ . . "S"^^ . "Antony"^^ . "S Antony"^^ . . "K"^^ . "Agama"^^ . "K Agama"^^ . . "Y"^^ . "Pommier"^^ . "Y Pommier"^^ . . "DP"^^ . "Curran"^^ . "DP Curran"^^ . . "D"^^ . "Yang"^^ . "D Yang"^^ . . "RS"^^ . "Tangirala"^^ . "RS Tangirala"^^ . . . . . . "Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin (Plain Text)"^^ . . . "licence.txt"^^ . . . "Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #19372 \n\nTotal and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin\n\n" . "text/html" . .