eprintid: 19348
rev_number: 22
userid: 1419
dir: disk0/00/01/93/48
datestamp: 2013-07-22 19:07:58
lastmod: 2019-02-02 16:57:51
status_changed: 2013-07-22 19:07:58
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Wright, CM
creators_name: Chovatiya, RJ
creators_name: Jameson, NE
creators_name: Turner, DM
creators_name: Zhu, G
creators_name: Werner, S
creators_name: Huryn, DM
creators_name: Pipas, JM
creators_name: Day, BW
creators_name: Wipf, P
creators_name: Brodsky, JL
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creators_email: pipas@pitt.edu
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creators_email: pwipf@pitt.edu
creators_email: jbrodsky@pitt.edu
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creators_id: PIPAS
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creators_id: PWIPF
creators_id: JBRODSKY
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creators_orcid: 0000-0002-6984-8486
title: Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. © 2007 Elsevier Ltd. All rights reserved.
date: 2008-03-15
date_type: published
publication: Bioorganic and Medicinal Chemistry
volume: 16
number: 6
pagerange: 3291 - 3301
refereed: TRUE
issn: 0968-0896
id_number: 10.1016/j.bmc.2007.12.014
other_id: NLM NIHMS45414
other_id: NLM PMC2330198
pmcid: PMC2330198
pmid: 18164205
mesh_headings: Adenosine Triphosphatases--metabolism
mesh_headings: Breast Neoplasms--drug therapy
mesh_headings: Cell Proliferation--drug effects
mesh_headings: Female
mesh_headings: HSP70 Heat-Shock Proteins--antagonists & inhibitors
mesh_headings: Humans
mesh_headings: Molecular Chaperones--drug effects
mesh_headings: Peptoids--chemistry
mesh_headings: Peptoids--pharmacology
mesh_headings: Pyrimidinones--chemistry
mesh_headings: Pyrimidinones--pharmacology
chemical_names: HSP70 Heat-Shock Proteins
chemical_names: Molecular Chaperones
chemical_names: Peptoids
chemical_names: Pyrimidinones
chemical_names: Adenosine Triphosphatases
citation:   Wright, CM and Chovatiya, RJ and Jameson, NE and Turner, DM and Zhu, G and Werner, S and Huryn, DM and Pipas, JM and Day, BW and Wipf, P and Brodsky, JL  (2008) Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.  Bioorganic and Medicinal Chemistry, 16 (6).  3291 - 3301.  ISSN 0968-0896     
document_url: http://d-scholarship-dev.library.pitt.edu/19348/1/licence.txt