%A CM Wright
%A RJ Chovatiya
%A NE Jameson
%A DM Turner
%A G Zhu
%A S Werner
%A DM Huryn
%A JM Pipas
%A BW Day
%A P Wipf
%A JL Brodsky
%J Bioorganic and Medicinal Chemistry
%T Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
%X The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. ? 2007 Elsevier Ltd. All rights reserved.
%N 6
%P 3291 - 3301
%V 16
%D 2008
%R 10.1016/j.bmc.2007.12.014
%L pittir19348