%0 Journal Article
%@ 0968-0896
%A Wright, CM
%A Chovatiya, RJ
%A Jameson, NE
%A Turner, DM
%A Zhu, G
%A Werner, S
%A Huryn, DM
%A Pipas, JM
%A Day, BW
%A Wipf, P
%A Brodsky, JL
%D 2008
%F pittir:19348
%J Bioorganic and Medicinal Chemistry
%N 6
%P 3291 - 3301
%T Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
%U http://d-scholarship-dev.library.pitt.edu/19348/
%V 16
%X The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. © 2007 Elsevier Ltd. All rights reserved.