relation: http://d-scholarship-dev.library.pitt.edu/19348/
title: Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
creator: Wright, CM
creator: Chovatiya, RJ
creator: Jameson, NE
creator: Turner, DM
creator: Zhu, G
creator: Werner, S
creator: Huryn, DM
creator: Pipas, JM
creator: Day, BW
creator: Wipf, P
creator: Brodsky, JL
description: The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. © 2007 Elsevier Ltd. All rights reserved.
date: 2008-03-15
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/19348/1/licence.txt
identifier:   Wright, CM and Chovatiya, RJ and Jameson, NE and Turner, DM and Zhu, G and Werner, S and Huryn, DM and Pipas, JM and Day, BW and Wipf, P and Brodsky, JL  (2008) Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.  Bioorganic and Medicinal Chemistry, 16 (6).  3291 - 3301.  ISSN 0968-0896     
relation: 10.1016/j.bmc.2007.12.014