@article{pittir19348,
          volume = {16},
          number = {6},
           month = {March},
          author = {CM Wright and RJ Chovatiya and NE Jameson and DM Turner and G Zhu and S Werner and DM Huryn and JM Pipas and BW Day and P Wipf and JL Brodsky},
           title = {Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation},
         journal = {Bioorganic and Medicinal Chemistry},
           pages = {3291 -- 3301},
            year = {2008},
             url = {http://d-scholarship-dev.library.pitt.edu/19348/},
        abstract = {The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. {\copyright} 2007 Elsevier Ltd. All rights reserved.}
}