%A S Keinan
%A WD Paquette
%A JJ Skoko
%A DN Beratan
%A W Yang
%A S Shinde
%A PA Johnston
%A JS Lazo
%A P Wipf
%J Organic and Biomolecular Chemistry
%T Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B
%X Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E1/2. ? 2008 The Royal Society of Chemistry.
%N 18
%P 3256 - 3263
%V 6
%D 2008
%R 10.1039/b806712k
%L pittir19276