relation: http://d-scholarship-dev.library.pitt.edu/19276/
title: Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B
creator: Keinan, S
creator: Paquette, WD
creator: Skoko, JJ
creator: Beratan, DN
creator: Yang, W
creator: Shinde, S
creator: Johnston, PA
creator: Lazo, JS
creator: Wipf, P
description: Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E1/2. © 2008 The Royal Society of Chemistry.
date: 2008-10-03
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/19276/1/licence.txt
identifier:   Keinan, S and Paquette, WD and Skoko, JJ and Beratan, DN and Yang, W and Shinde, S and Johnston, PA and Lazo, JS and Wipf, P  (2008) Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.  Organic and Biomolecular Chemistry, 6 (18).  3256 - 3263.  ISSN 1477-0520     
relation: 10.1039/b806712k