eprintid: 19239
rev_number: 17
userid: 1346
importid: 1894
dir: disk0/00/01/92/39
datestamp: 2013-07-15 20:00:50
lastmod: 2019-02-02 13:55:09
status_changed: 2013-07-15 20:00:50
type: article
metadata_visibility: show
contact_email: rstall@pitt.edu
item_issues_count: 0
eprint_status: archive
creators_name: Plankey, MW
creators_name: Ostrow, DG
creators_name: Stall, R
creators_name: Cox, C
creators_name: Li, X
creators_name: Peck, JA
creators_name: Jacobson, LP
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creators_email: rstall@pitt.edu
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creators_id: 
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creators_id: RSTALL
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title: The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study
ispublished: pub
divisions: sch_gsph_behavioralcommhealthsci
full_text_status: public
abstract: BACKGROUND: The association between methamphetamine use and HIV seroconversion for men who have sex with men (MSM) was examined using longitudinal data from the Multicenter AIDS Cohort Study. METHODS: Seronegative (n = 4003) men enrolled in 1984 to 1985, 1987 to 1991, and 2001 to 2003 were identified. Recent methamphetamine and popper use was determined at the current or previous visit. Time to HIV seroconversion was the outcome of interest. Covariates included race/ethnicity, cohort, study site, educational level, number of sexual partners, number of unprotected insertive anal sexual partners, number of unprotected receptive anal sexual partners, insertive rimming, cocaine use at the current or last visit, ecstasy use at the current or last visit, any needle use since the last visit, Center for Epidemiologic Study of Depression symptom checklist score >16 since the last visit, and alcohol consumption. RESULTS: After adjusting for covariates, there was a 1.46 (95% confidence interval [CI]: 1.12 to 1.92) increased relative hazard of HIV seroconversion associated with methamphetamine use. The relative hazard associated with popper use was 2.10 (95% CI: 1.63 to 2.70). The relative hazard of HIV seroconversion increased with the number of unprotected receptive anal sexual partners, ranging from 1.87 (95% CI: 1.40 to 2.51) for 1 partner to 9.32 (95% CI: 6.21 to 13.98) for 5+ partners. The joint relative hazard for methamphetamine and popper use was 3.05 (95% CI: 2.12 to 4.37). There was a significant joint relative hazard for methamphetamine use and number of unprotected receptive anal sexual partners of 2.71 (95% CI: 1.81 to 4.04) for men with 1 unprotected receptive anal sexual partner, which increased in a dose-dependent manner for >1 partners. CONCLUSIONS: Further examination of the mechanisms underlying the synergism of drug use and sexual risk behaviors on rates of HIV seroconversion is necessary for the development of new targeted HIV prevention strategies for nonmonogamous drug-using MSM. © 2007 Lippincott Williams & Wilkins, Inc.
date: 2007-05-01
date_type: published
publication: Journal of Acquired Immune Deficiency Syndromes
volume: 45
number: 1
pagerange: 85 - 92
refereed: TRUE
issn: 1525-4135
centers: cen_other_lgbthealth
id_number: 10.1097/QAI.0b013e3180417c99
other_id: NLM NIHMS410308
other_id: NLM PMC3486782
pmcid: PMC3486782
pmid: 17325605
mesh_headings: Acquired Immunodeficiency Syndrome--epidemiology
mesh_headings: Acquired Immunodeficiency Syndrome--transmission
mesh_headings: Adult
mesh_headings: Cohort Studies
mesh_headings: HIV Seropositivity--epidemiology
mesh_headings: HIV Seropositivity--transmission
mesh_headings: Homosexuality, Male
mesh_headings: Humans
mesh_headings: Male
mesh_headings: Methamphetamine
mesh_headings: Multicenter Studies as Topic
mesh_headings: Multivariate Analysis
mesh_headings: N-Methyl-3,4-methylenedioxyamphetamine
mesh_headings: Risk Factors
mesh_headings: Sexual Behavior
mesh_headings: Sexual Partners
mesh_headings: Substance-Related Disorders--epidemiology
mesh_headings: Time Factors
chemical_names: N-Methyl-3,4-methylenedioxyamphetamine
chemical_names: Methamphetamine
citation:   Plankey, MW and Ostrow, DG and Stall, R and Cox, C and Li, X and Peck, JA and Jacobson, LP  (2007) The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study.  Journal of Acquired Immune Deficiency Syndromes, 45 (1).  85 - 92.  ISSN 1525-4135     
document_url: http://d-scholarship-dev.library.pitt.edu/19239/1/licence.txt