eprintid: 18975 rev_number: 15 userid: 1346 importid: 1851 dir: disk0/00/01/89/75 datestamp: 2013-06-25 19:38:44 lastmod: 2019-02-02 16:57:42 status_changed: 2013-06-25 19:38:44 type: article metadata_visibility: show contact_email: rdc27@pitt.edu item_issues_count: 0 eprint_status: archive creators_name: Chin-Hong, PV creators_name: Husnik, M creators_name: Cranston, RD creators_name: Colfax, G creators_name: Buchbinder, S creators_name: Da Costa, M creators_name: Darragh, T creators_name: Jones, D creators_name: Judson, F creators_name: Koblin, B creators_name: Mayer, KH creators_name: Palefsky, JM creators_email: creators_email: creators_email: rdc27@pitt.edu creators_email: creators_email: creators_email: creators_email: creators_email: creators_email: creators_email: creators_email: creators_email: creators_id: creators_id: creators_id: RDC27 creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: title: Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men ispublished: pub divisions: sch_gsph_infectiousdiseasesmicrobiology full_text_status: public abstract: OBJECTIVE:: Human papillomavirus (HPV) is a common sexually transmitted agent that causes anogenital cancer and precancer lesions that have an inflammatory infiltrate, may be friable and bleed. Our aim was to determine the association between anal HPV infection and HIV acquisition. DESIGN:: A prospective cohort study. METHODS:: We recruited 1409 HIV-negative men who have sex with men from a community-based setting in Boston, Denver, New York and San Francisco. We used Cox proportional hazards regression modeling and assessed the independent association of HPV infection with the rate of acquisition of HIV infection. RESULTS:: Of 1409 participants contributing 4375 person-years of follow-up, 51 HIV-seroconverted. The median number of HPV types in HPV-infected HIV-seroconverters was 2 (interquartile range 1-3) at the time of HIV seroconversion. After adjustment for sexual activity, substance use, occurrence of other sexually transmitted infections and demographic variables, there was evidence (P = 0.002) for the effect of infection with at least two HPV types (hazard ratio 3.5, 95% confidence interval 1.2-10.6) in HIV seroconversion. CONCLUSION:: Anal HPV infection is independently associated with HIV acquisition. Studies that incorporate high-resolution anoscopy to more accurately identify HPV-associated disease are needed to determine the relationship between HPV-associated disease and HIV seroconversion. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. date: 2009-06-01 date_type: published publication: AIDS volume: 23 number: 9 pagerange: 1135 - 1142 refereed: TRUE issn: 0269-9370 centers: cen_other_lgbthealth id_number: 10.1097/QAD.0b013e32832b4449 pmid: 19390418 mesh_headings: Adult mesh_headings: Anus Diseases--virology mesh_headings: Boston mesh_headings: HIV Seropositivity--transmission mesh_headings: HIV Seropositivity--virology mesh_headings: HIV-1 mesh_headings: Homosexuality, Male mesh_headings: Humans mesh_headings: Male mesh_headings: Middle Aged mesh_headings: New York mesh_headings: Papillomavirus Infections--transmission mesh_headings: Papillomavirus Infections--virology mesh_headings: Precancerous Conditions--virology mesh_headings: Prospective Studies mesh_headings: RNA, Viral mesh_headings: San Francisco chemical_names: RNA, Viral citation: Chin-Hong, PV and Husnik, M and Cranston, RD and Colfax, G and Buchbinder, S and Da Costa, M and Darragh, T and Jones, D and Judson, F and Koblin, B and Mayer, KH and Palefsky, JM (2009) Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men. AIDS, 23 (9). 1135 - 1142. ISSN 0269-9370 document_url: http://d-scholarship-dev.library.pitt.edu/18975/1/licence.txt