TY  - JOUR
ID  - pittir18954
UR  - http://d-scholarship-dev.library.pitt.edu/18954/
IS  - 5
A1  - Hopkins, CD
A1  - Wipf, P
Y1  - 2009/05/05/
N2  - The disorazoles comprise a family of 29 closely related macrocyclic polyketides isolated in 1994 from the fermentation broth of the gliding myxobacterium Sorangium cellulosum. Disorazoles A1, E and C 1 have shown exceptional biological activities toward inhibiting the proliferation of human cancer cell lines in picomolar and nanomolar concentrations through the disruption of microtubule polymerization. This review gives a brief introduction describing the biosynthesis and the significance of the disorazoles as a new class of microtubulin disruptors. Another portion of the review focuses on the biology of the disorazoles, specifically disorazole A1 and C1, and their antiproliferative efficacy against animal and human tumor cell lines, as well as the available SAR data. The majority of the discussion addresses synthetic efforts, including partial syntheses of various disorazoles and a summary of the total synthesis of disorazole C1. © 2009 The Royal Society of Chemistry.
JF  - Natural Product Reports
VL  - 26
SN  - 0265-0568
TI  - Isolation, biology and chemistry of the disorazoles: New anti-cancer macrodiolides
SP  - 585 
AV  - public
EP  -  601
ER  -