eprintid: 18941
rev_number: 30
userid: 1419
dir: disk0/00/01/89/41
datestamp: 2013-06-12 20:31:40
lastmod: 2021-03-10 06:25:41
status_changed: 2013-06-12 20:31:40
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Kagan, VE
creators_name: Bayir, HA
creators_name: Belikova, NA
creators_name: Kapralov, O
creators_name: Tyurina, YY
creators_name: Tyurin, VA
creators_name: Jiang, J
creators_name: Stoyanovsky, DA
creators_name: Wipf, P
creators_name: Kochanek, PM
creators_name: Greenberger, JS
creators_name: Pitt, B
creators_name: Shvedova, AA
creators_name: Borisenko, G
creators_email: kagan@pitt.edu
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creators_email: jjf73@pitt.edu
creators_email: das11@pitt.edu
creators_email: pwipf@pitt.edu
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creators_email: joelg@pitt.edu
creators_email: brucep@pitt.edu
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creators_id: KAGAN
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creators_id: JJF73
creators_id: DAS11
creators_id: PWIPF
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creators_id: BRUCEP
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creators_orcid: 0000-0001-5591-4780
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title: Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria-its asymmetric transmembrane distribution and mechanisms of collapse, the regulation of its synthesis, remodeling, and fatty acid composition-are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented.
date: 2009-06-01
date_type: published
publication: Free Radical Biology and Medicine
volume: 46
number: 11
pagerange: 1439 - 1453
refereed: TRUE
issn: 0891-5849
id_number: 10.1016/j.freeradbiomed.2009.03.004
article_type: review
other_id: NLM NIHMS102249
other_id: NLM PMC2732771
pmcid: PMC2732771
pmid: 19285551
mesh_headings: Animals
mesh_headings: Apoptosis
mesh_headings: Cardiolipins--physiology
mesh_headings: Cytochromes c--physiology
mesh_headings: Humans
mesh_headings: Lipid Peroxidation--physiology
mesh_headings: Mitochondria--physiology
mesh_headings: Oxidative Stress
mesh_headings: Protein Binding
mesh_headings: Signal Transduction
chemical_names: Cardiolipins
chemical_names: Cytochromes c
citation:   Kagan, VE and Bayir, HA and Belikova, NA and Kapralov, O and Tyurina, YY and Tyurin, VA and Jiang, J and Stoyanovsky, DA and Wipf, P and Kochanek, PM and Greenberger, JS and Pitt, B and Shvedova, AA and Borisenko, G  (2009) Cytochrome c/cardiolipin relations in mitochondria: a kiss of death.  Free Radical Biology and Medicine, 46 (11).  1439 - 1453.  ISSN 0891-5849     
document_url: http://d-scholarship-dev.library.pitt.edu/18941/1/licence.txt