<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Cytochrome c/cardiolipin relations in mitochondria: a kiss of death"^^ . "Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria-its asymmetric transmembrane distribution and mechanisms of collapse, the regulation of its synthesis, remodeling, and fatty acid composition-are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented."^^ . "2009-06-01" . . "46" . "11" . . "Free Radical Biology and Medicine"^^ . . . "08915849" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "O"^^ . "Kapralov"^^ . "O Kapralov"^^ . . "AA"^^ . "Shvedova"^^ . "AA Shvedova"^^ . . "PM"^^ . "Kochanek"^^ . "PM Kochanek"^^ . . "HA"^^ . "Bayir"^^ . "HA Bayir"^^ . . "JS"^^ . "Greenberger"^^ . "JS Greenberger"^^ . . "VA"^^ . "Tyurin"^^ . "VA Tyurin"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "G"^^ . "Borisenko"^^ . "G Borisenko"^^ . . "B"^^ . "Pitt"^^ . "B Pitt"^^ . . "YY"^^ . "Tyurina"^^ . "YY Tyurina"^^ . . "J"^^ . "Jiang"^^ . "J Jiang"^^ . . "DA"^^ . "Stoyanovsky"^^ . "DA Stoyanovsky"^^ . . "VE"^^ . "Kagan"^^ . "VE Kagan"^^ . . "NA"^^ . "Belikova"^^ . "NA Belikova"^^ . . . . . . "Cytochrome c/cardiolipin relations in mitochondria: a kiss of death (Plain Text)"^^ . . . "licence.txt"^^ . . . "Cytochrome c/cardiolipin relations in mitochondria: a kiss of death (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #18941 \n\nCytochrome c/cardiolipin relations in mitochondria: a kiss of death\n\n" . "text/html" . .