?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F18940%2F&rft.title=Aerosolized+Influenza+Infection+During+Late+Gestation+Pregnancy+in+the+Ferrot+Model&rft.creator=Gage%2C+Emily&rft.description=Human+pregnancy+is+known+to+predispose+women+to+disproportionate+morbidity+and+mortality+from+influenza+infection.++Limited+investigation+has+been+performed+to+understand+the+mechanism(s)+of+increased+risk.++Investigation+of+a+pregnant+ferret+model+was+undertaken+using+aerosolized+2009+pH1N1+influenza.++Pregnant+ferrets+demonstrated+worse+clinical+disease+and+increased+pro-inflammatory+cytokine+gene+expression+levels%2C+notably+IL-6+and+IL-10+in+the+lung+and+at+the+maternal%2Ffetal+interface+but+not+the+spleen.+Influenza+virus+was+detected+by+semi-quantitative+RT-PCR+in+many+tissues+including+the+placenta+and+kits+but+not+the+uterus+of+the+non-pregnant+ferrets%2C+suggesting+placental-fetal+transmission.+No+obvious+difference+in+lung+pathology+was+observed+between+the+pregnant+and+age-matched+controls.+Further+model+development+is+warranted+to+elucidate+mechanisms+that+cause+greater+disease+during+pregnancy+and+effects+of+maternal+disease+on+fetal+outcomes.+Ultimately%2C+this+model+would+further+aid+in+investigating+countermeasures+against+influenza+during+pregnancy.+The+public+health+significance+of+this+study+is+that+by+establishing+a+pertinent+influenza+pregnant+animal+model%2C+answers+to+translational+questions+about+the+effectiveness+of+therapeutics+and+when+treatment+would+be+most+effective+could+be+investigated%2C+potentially+lowering+the+amount+of+lives+lost%2Chospitalization+rates%2C+and+economic+burden+caused+by+this+health+disparity.&rft.date=2013-06-27&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F18940%2F1%2FGage_E_Thesis5.pdf&rft.identifier=++Gage%2C+Emily++(2013)+Aerosolized+Influenza+Infection+During+Late+Gestation+Pregnancy+in+the+Ferrot+Model.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++