%0 Journal Article
%@ 0960-894X
%A Sarachine, MJ
%A Janjic, JM
%A Wipf, P
%A Day, BW
%D 2009
%F pittir:18879
%J Bioorganic and Medicinal Chemistry Letters
%N 9
%P 2404 - 2408
%T Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor β
%U http://d-scholarship-dev.library.pitt.edu/18879/
%V 19
%X The C-cyclopropylalkylamide scaffold was previously identified as a new structural framework for antiestrogens. A second generation library provided three compounds that bind estrogen receptor (ER)α. Further screening of this library identified an ERβ hit and inspired another round of SAR. A new focused library was tested for binding to the ERs, and for effects on the growth of breast cancer cell lines and protein levels of common cell cycle regulators. © 2009 Elsevier Ltd. All rights reserved.