%0 Journal Article
%@ 1477-0520
%A Wipf, P
%A Mo, T
%A Geib, SJ
%A Caridha, D
%A Dow, GS
%A Gerena, L
%A Roncal, N
%A Milner, EE
%D 2009
%F pittir:18848
%J Organic and Biomolecular Chemistry
%N 20
%P 4163 - 4165
%T Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine
%U http://d-scholarship-dev.library.pitt.edu/18848/
%V 7
%X Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines. © 2009 The Royal Society of Chemistry.