?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F18841%2F&rft.title=In+Vivo+Human+Right+Ventricle+Shape+and+Kinematic+Analysis+with+and+without+Pulmonary+Hypertension&rft.creator=Wu%2C+Jia&rft.description=Pulmonary+hypertension+(PH)+is+a+severe+cardio-pulmonary+illness+which+has+been+commonly+observed+to+induce+substantial+and+ultimately+deleterious+changes+to+the+human+right+ventricle+(RV)+shape+and+function.+As+such%2C+the+functional+state+of+the+RV+is+thought+to+be+a+major+determinant+of+symptoms+and+survival+rates+for+PH.++However%2C+there+has+been+little+success+to-date+to+identify+clinically+obtainable+metrics+of+RV+shape+and+deformation+as+a+means+to+detect+the+onset+and+progression+of+PH.+This+difficulty+is+largely+the+result+of+the+absence+of+a+proven+approach+that+is+generally+applicable+for+consistent+and+reliable+quantitative+analysis+of+anatomical+shapes%2C+particularly+the+RV%2C+between+patients+and+over+time.%0D%0ATherefore%2C+a+computational+framework+which+can+quantitatively+analyze+RV+shape+and+deformation+could+be+a+key+to+assist+in+clinically+detecting+the+onset+and+progression+of+PH.%0D%0A%0D%0AStatistical+shape+analysis+techniques+were+developed%2C+implemented%2C+and+assessed+to+analyze+variations+in+human+RV+endocardial+surface+(RVES)+shapes+and+kinematics+from+noninvasive+clinical+medical+imaging+data+with+respect+to+a+spectrum+of+hemodynamic+states.++%0D%0AA+computational+framework+for+the+quantitative+analysis+and+statistical+decomposition+of+sets+of+3D+genus-0+shapes+that+combines+a+modified+harmonic+mapping+approach+directly+with+proper+orthogonal+decomposition+(DM-POD)+is+presented.++The+DM-POD+approach+is+shown+to+be+a+robust+technique+for+recovering+inherent+shape-related+features+through+the+analysis+of+sets+of+artificially+generated+shapes.++%0D%0AThe+DM-POD+approach+is+then+applied+to+obtain+kinematic+features+of+the+human+RV+based+on+the+relative+change+in+shape+of+the+endocardial+surface+using+cardiac+computed+tomography+images.++%0D%0AIn+addition%2C+the+kinematic+features+of+the+RVES+obtained+by+the+DM-POD+approach+are+shown+to+be+consistent+and+associated+with+intrinsically+physiological+components+of+the+heart%2C+and+thus+may+potentially+provide+a+more+accurate+means+for+classifying+the+progressive+change+in+RV+function+caused+by+PH%2C+in+comparison+to+traditional+clinical+hemodynamic+and+volume-based+metrics.%0D%0AStatistical+shape+analysis+for+the+human+RV+is+further+evaluated+through+analysis+of+alternate+components+of+the+DM-POD+approach%2C+as+well+as+through+comparison+of+the+DM-POD+workflow+with+an+alternate+spherical+harmonic+function-based+workflow+(SPHARM)%2C+with+respect+to+the+aspects+of+surface+representation%2C+alignment%2C+and+decomposition.%0D%0AAdditionally%2C+different+ways+of+utilizing+the+available+imaging+data+with+respect+to+the+classification+potential+are+investigated+by+considering+analysis+results+when+applying+both+the+various+DM-POD+and+SPHARM+approaches+with+several+different+combinations+of+the+phases+captured+throughout+a+single+cardiac+cycle+for+the+patient+set.+%0D%0ALastly%2C+a+novel+statistical+decomposition+technique+known+as+independent+component+analysis+(ICA)+was+incorporated+into+the+statistical+shape+analysis+framework+(i.e.%2C+DM-POD)+to+produce+an+alternative+workflow+(DM-ICA).+Both+the+DM-POD+and+DM-ICA+approaches+are+applied+to+analyze+sets+of+artificially+generated+data+and+the+human+RVES+datasets%2C+and+the+respective+results+are+compared.%0D%0AThe+DM-POD+and+DM-ICA+workflows+are+shown+to+produce+consistent%2C+but+substantially+different+results+due+to+the+various+principles+and+views+of+each+of+the+two+statistical+decomposition+algorithms+(i.e.%2C+POD+and+ICA).%0D%0AMost+importantly%2C+the+results+from+the+DM-POD+and+DM-ICA+workflows+appear+to+relate+to+RV+function+in+unique+ways%2C+with+respect+to+both+traditional+clinical+metrics+and+each+other%2C+and+have+the+potential+to+provide+new+metrics+for+better+understanding+of+the+human+RV+and+its+relationship+to+PH.&rft.date=2013-09-25&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F18841%2F1%2FWu_etd2013.pdf&rft.identifier=++Wu%2C+Jia++(2013)+In+Vivo+Human+Right+Ventricle+Shape+and+Kinematic+Analysis+with+and+without+Pulmonary+Hypertension.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++