<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model"^^ . "We studied radioprotection and mitigation by mitochondrial-targeted Tempol (GS-nitroxide, JP4-039), in a mouse injury/irradiation model of combined injury (fracture/irradiation). Right hind legs of control C57BL/6NHsd female mice, mice pretreated with MnSOD-PL, JP4-039, or with amifostine were irradiated with single and fractionated doses of 0 to 20 Gy. Twenty-four hours later, unicortical holes were drilled into the tibiae of both hind legs; at intervals, tibias were excised, radiographed, and processed for histology. Bone wounds irradiated to 20 or 30 Gy showed delayed healing at 21 to 28 days. Treatment with JP4-039 MnSOD-PL or amifostine, before or after single fraction 20 Gy or during fractionated irradiation followed by drilling accelerated wound healing at days 21 and 28. Orthotopic 3LL tumors were not protected by JP4-039 or amifostine. In nonirradiated mice, pretreatment with JP4-039 accelerated bone wound healing. This test system should be useful for the development of new small molecule radioprotectors."^^ . "2010-01-01" . . "24" . "4" . . "In Vivo"^^ . . . "0258851X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "JP"^^ . "Goff"^^ . "JP Goff"^^ . . "A"^^ . "Gokhale"^^ . "A Gokhale"^^ . . "JS"^^ . "Greenberger"^^ . "JS Greenberger"^^ . . "K"^^ . "Patrene"^^ . "K Patrene"^^ . . "H"^^ . "Wang"^^ . "H Wang"^^ . . "JC"^^ . "Rwigema"^^ . "JC Rwigema"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "MW"^^ . "Epperly"^^ . "MW Epperly"^^ . . "T"^^ . "Dixon"^^ . "T Dixon"^^ . . "J"^^ . "Glowacki"^^ . "J Glowacki"^^ . . . . . . "Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model (Plain Text)"^^ . . . "licence.txt"^^ . . . "Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #18777 \n\nSmall molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model\n\n" . "text/html" . .