TY  - JOUR
ID  - pittir18773
UR  - http://d-scholarship-dev.library.pitt.edu/18773/
IS  - 3
A1  - Pizzo, C
A1  - Saiz, C
A1  - Talevi, A
A1  - Gavernet, L
A1  - Palestro, P
A1  - Bellera, C
A1  - Blanch, LB
A1  - Benítez, D
A1  - Cazzulo, JJ
A1  - Chidichimo, A
A1  - Wipf, P
A1  - Mahler, SG
Y1  - 2011/03/01/
N2  - A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-?,?-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37?m concentration in the enzyme assay. Computational tools and docking were used to correlate the biological response with the physicochemical parameters of the compounds and their cruzipain inhibitory effects. © 2011 John Wiley & Sons A/S.
JF  - Chemical Biology and Drug Design
VL  - 77
SN  - 1747-0277
TI  - Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
SP  - 166 
AV  - public
EP  -  172
ER  -