%0 Journal Article
%@ 0968-0896
%A Tangirala, RS
%A Antony, S
%A Agama, K
%A Pommier, Y
%A Anderson, BD
%A Bevins, R
%A Curran, DP
%D 2006
%F pittir:18754
%J Bioorganic and Medicinal Chemistry
%N 18
%P 6202 - 6212
%T Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
%U http://d-scholarship-dev.library.pitt.edu/18754/
%V 14
%X Analogs of the anti-tumor agent camptothecin with both closed E-rings (lactone and ether) and open E-rings (reduced acid, hydrazide, and protected Weinreb amide) have been prepared and tested in topoisomerase and cellular assays. The results provide insights into the structural features of the camptothecin E-ring that affect biological activity. © 2006 Elsevier Ltd. All rights reserved.