TY  - JOUR
ID  - pittir18744
UR  - http://d-scholarship-dev.library.pitt.edu/18744/
IS  - 9
A1  - Frantz, MC
A1  - Pierce, JG
A1  - Pierce, JM
A1  - Kangying, L
A1  - Qingwei, W
A1  - Johnson, M
A1  - Wipf, P
Y1  - 2011/05/06/
N2  - Chemical equations presented. JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation- transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure. © 2011 American Chemical Society.
JF  - Organic Letters
VL  - 13
SN  - 1523-7060
TI  - Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs
SP  - 2318 
AV  - public
EP  -  2321
ER  -