%A W Zhang
%A DP Curran
%J Tetrahedron
%T Synthetic applications of fluorous solid-phase extraction (F-SPE)
%X The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 ? 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.
%N 51
%P 11837 - 11865
%V 62
%D 2006
%R 10.1016/j.tet.2006.08.051
%L pittir18729