%0 Journal Article
%@ 0040-4020
%A Zhang, W
%A Curran, DP
%D 2006
%F pittir:18729
%J Tetrahedron
%N 51
%P 11837 - 11865
%T Synthetic applications of fluorous solid-phase extraction (F-SPE)
%U http://d-scholarship-dev.library.pitt.edu/18729/
%V 62
%X The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.