relation: http://d-scholarship-dev.library.pitt.edu/18729/
title: Synthetic applications of fluorous solid-phase extraction (F-SPE)
creator: Zhang, W
creator: Curran, DP
description: The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.
date: 2006-12-18
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/18729/1/licence.txt
identifier:   Zhang, W and Curran, DP  (2006) Synthetic applications of fluorous solid-phase extraction (F-SPE).  Tetrahedron, 62 (51).  11837 - 11865.  ISSN 0040-4020     
relation: 10.1016/j.tet.2006.08.051